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目的：分析下呼吸道感染病原菌特点及耐药性。方法回顾100例下呼吸道感染患者临床资料，对其病原菌分布特点及耐药情况进行分析。结果革兰阴性菌67.6%、革兰阳性菌18.1%、真菌14.3%，主要病原菌有铜绿假单细胞菌、肺炎克雷伯菌、金黄色葡萄球菌、大肠埃希菌，革兰阴性菌对哌拉西林、头孢他啶的耐药率较高，革兰阳性菌则对氨芐西林的耐药率较高。结论下呼吸道感染病原菌以革兰阴性菌为主，临床医师应根据病原菌特点及其耐药情况，合理使用抗菌药物。“,”Objective In order to analysis pathogenic characteristics and drug resistance in lower respiratory tract infection.Methods By the retrospective methods,we analyzed the pathogens isoated from the sputa of the 100 cases patients with lower respiratory tract infection and their drug resistance.Results There were 67.6%strains of Gram-negative bacilli,18.1%strains of Gram-positive bacteria and14.3%strains of fungi.The main pathogens were P.aeruginosa,Klebsiella pneumoniae,Staphylococcus aureus,Escherichia coli.The resistance rate of Piperacillin and Cephalosporins to Gram-negative bacteria were higher,while the resistance rate of Ampicillin to Gram-positive bacteria were higher.Conclusion The main pathogens in lower respiratory tract infection are Gram-negative bacteria.Clinicians should use antibiotics Rationally,based on pathogenic characteristics and drug resistance.