糖尿病合并症的病因除与高血糖状态直接相关外,还与醛糖还原酶(AR)催化的多元醇代谢亢进有关。当AR活性被抑制时,糖尿病合并症的发生发展可停止或延迟,基于这种假定研制出的药物称AR抑制剂。一、多元醇代谢与糖尿病合并症多元醇(山梨醇、甘油醇、木糖醇、肌醇等)由醛糖还原生成,其中的山梨醇直接由葡萄糖生成,推 In addition to the cause of diabetic complications is directly related to the state of hyperglycemia, but also with aldose reductase (AR) catalyzed polyol hypermetabolism. When the AR activity is inhibited, the development of diabetic complications can be stopped or delayed, based on the assumption that the drug developed AR inhibitors. First, the polyhydric alcohol metabolism and diabetes complications Polyols (sorbitol, glycerol, xylitol, inositol, etc.) formed by the aldose reduction, in which the sorbitol is generated directly from glucose, pushing