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１９９５～１９９７年在河北省邯郸、衡水、保定３个市对１～４代棉铃虫幼虫进行了调查，结果表明：能够抑制棉铃虫种群数量变动及导致疾病发生与流行的主要病原菌种类有病毒，包括核型多角体病毒、质型多角体病毒和颗粒体病毒；细菌为苏云金杆菌；真菌有绿僵菌和白僵菌。因感病致死的棉铃虫视年度、世代不同而差异显著，平均死亡率为２１．１％，高的可达５７．１％。研究还表明：棉铃虫疾病的发生及流行与宿主种群、病原菌种群及环境因素关系密切。
From 1995 to 1997, 1-4 generations of cotton bollworm larvae were investigated in three cities of Handan, Hengshui and Baoding in Hebei Province. The results showed that the main pathogens that could inhibit the population fluctuation and the occurrence and prevalence of H. armigera were viruses, Including nuclear polyhedrosis virus, polyhedrosis virus and granulovirus body; Bacillus thuringiensis bacteria; Metarhizium anisopliae and Beauveria bassiana. The susceptible strains of Helicoverpa armigera were significantly different from one generation to the next, with an average mortality rate of 21.1% and a high of 57.1%. The research also shows that the occurrence and prevalence of the disease are closely related to the host population, pathogen population and environmental factors.