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目的探究不同浓度及滴度催产素静脉滴注对妊娠糖尿病(GDM)患者的影响。方法选取上高县人民医院2016年8月—2017年8月收治的GDM患者40例为观察组,另选取本院同期非GDM患者40例为对照组,依据不同的滴速调节方式(等差/等比)、输注浓度(5、10 m U/ml)分别将两组患者分为甲1、甲2、乙1、乙2。患者均采用催产素引产,对比各组新生儿窒息率、引产开始至最佳有效宫缩时间、引产成功率、不良反应发生率、催产素用量。结果相较于对照组,观察组患者在滴速及浓度相同的情况下,催产素用量大于对照组,至最佳宫缩时间长于对照组(P<0.05);观察组至最佳宫缩时间,乙2组最短,甲1组最长,而相较于乙2组,甲2显著较长(P<0.05)。结论 GDM会明显降低产妇对催产素引产的敏感性,催产素从8滴/min、10 m U/ml起进行等比递增调控最有效安全。
Objective To investigate the effects of different concentrations and titer of intravenous oxytocin on gestational diabetes mellitus (GDM). Methods 40 cases of GDM patients who were treated in Shanggao People’s Hospital from August 2016 to August 2017 were selected as the observation group and 40 cases of non-GDM patients in the same period of the hospital were selected as the control group. According to different drip rate adjustment methods / Equal ratio), the infusion concentration (5,10 mU / ml) were divided into two groups of patients A 1, A 2, B 1, B 2. Patients were using oxytocin induction of labor, neonatal asphyxia compared to each group, induction of labor to start the best effective contractions time, the success rate of induction of labor, the incidence of adverse reactions, the amount of oxytocin. Results Compared with the control group, in the observation group, the dosage of oxytocin was higher than that of the control group at the same drip rate and concentration, and the optimal time of contractions was longer than that of the control group (P <0.05) , Group B was the shortest, group A was the longest, and group A was significantly longer than group B (P <0.05). Conclusion GDM significantly reduces the sensitivity of maternal to induction of oxytocin. Oxytocin regulates the most effective and safe from 8 drops / min, 10 m U / ml.