铁在细胞功能中有着重要的生理作用,然而未与蛋白质结合的游离铁,特别是二价铁离子对机体是有害的,铁能催化自由基的生成,导致氧化应激。机体内有多种机制控制细胞内的铁稳态。肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是一种进行性的神经退行性变性疾病,以脊髓、皮? Iron plays an important physiological role in cell function. However, free iron, especially ferrous iron, that is not bound to protein is harmful to the body. Iron can catalyze the production of free radicals and cause oxidative stress. There are many mechanisms in the body to control intracellular iron homeostasis. Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that involves the spinal cord, skin,