恶性石骨症为发生在幼儿的罕见泛发性骨硬化病,而出现广泛骨膜反应至今未见报道,现将我院所见1例报告如下。患者男,3月。因发热、消瘦前来本院就诊。患儿出生后第13天出现低热伴皮肤巩膜黄染,当地医院发现肝脾肿大,肝功能正常,给予抗炎治疗后体温恢复正常,继后病情反复,进行性消瘦转来我院。患儿系二胎二产,足月顺产,人工喂养,父母非近亲婚配,家族中无传染病及遗传病患者。体检:T37.9℃,P120次,R30次,体重5kg。神清,精神萎,营养差。头围43cm,囟门大(前囟5cm×5cm),颅缝分离,双目似落日样,皮肤巩膜无黄染,前肋呈串珠样突起。腹膨隆,腹壁皮下层菲薄,肝肋下5cm,质 Malignant spondylosis occurs in young children with common primary osteopetrosis, and there have been no reports of extensive periosteal reaction, now see a hospital in our report as follows. Patient male, March. Due to fever, weight loss came to our hospital. Children born on the thirteenth day of low fever with scleral skin yellow dye, liver and spleen found in the local hospital, normal liver function, given anti-inflammatory body temperature returned to normal, followed by repeated illness, progressive weight loss to our hospital. Pediatric second-born second-born, term full-term, artificial feeding, non-relatives of parents and marriage, the family of non-infectious and genetic diseases. Physical examination: T37.9 ℃, P120 times, R30 times, weight 5kg. Clear, spiritual wilts, poor nutrition. Head circumference 43cm, fontanelle (anterior fontanel 5cm × 5cm), cranial suture separation, like the sun like the eyes, the skin sclera no yellow dye, anterior beriberi-like protuberance. Abdominal bulge, abdominal wall meager, liver rib 5cm, quality