目的评价采用吡南阿霉素 ( THP)与环磷酰胺 ( CTX)及顺铂 ( DDP)联合化疗治疗晚期乳腺癌的疗效与毒性反应。方法晚期乳腺癌 13 5例 ,采用第一天分别静脉注射 THP40 mg/m2 ,CTX60 0 mg/m2 ,同时 DDP2 0 mg/m2 ,静脉滴注 ,第 1～ 5天。 2 1天为一疗程。结果总有效率 78.1% ,完全缓解率 19.3 % ,初治者总有效率 10 0 %。该方案胃肠道反应轻 ,轻度脱发 ( 11.1% ) ,白细胞减少 96.3 % ,多为 、 度 ( 66.7% )。结论 THP联合 CTX与 DDP化疗治疗晚期乳腺癌疗效高 ,毒性低。 Objective To evaluate the efficacy and toxicity of the combination of dipyridamycin (THP) and cyclophosphamide (CTX) and cisplatin (DDP) in the treatment of advanced breast cancer. Methods One hundred and thirty-five patients with advanced breast cancer were treated with intravenous THP 40 mg / m2, CTX60 0 mg / m2, and DDP2 0 mg / m2 iv on the first day. 2 1 days for a course of treatment. Results The total effective rate was 78.1%, the complete remission rate was 19.3%, and the initial effective rate was 100%. The program gastrointestinal reactions light, mild hair loss (11.1%), leukopenia 96.3%, mostly, degree (66.7%). Conclusion THP combined with CTX and DDP chemotherapy for the treatment of advanced breast cancer with high efficacy and low toxicity.