C6细胞是大鼠经化学致癌剂N-亚硝基甲脲体内诱发产生的脑胶质瘤细胞,具有较典型的人脑胶质瘤组织学特点。大鼠脑内立体定向接种C6细胞建立的动物模型,因成瘤高、动物手术死亡率低,所以广泛应用于脑胶质瘤治疗的研究中。国外研究发现,来源于非纯种大鼠的C6细胞具有很强的免疫原性:其主要组织相容性基因复合体中存在与大鼠呈异源性的基因;C6细胞接种于大鼠体内引发强烈的免疫排斥反应可使肿瘤不能持续生长甚至自行消退,因此混淆了治疗所产生的效应,尤其当用于免疫和基因免疫治疗的研究时,存在较大缺陷。 C6 cells are the brain glioma cells induced by the chemical carcinogen N-nitrosomethyluridine in vivo and have the histological characteristics of typical human glioma. Animal models established by stereotactic inoculation of C6 cells in the brain of rats have been widely used in the study of glioma treatment due to their high tumorigenicity and low surgical mortality. Foreign studies found that C6 cells derived from non-purebred rats have strong immunogenicity: the major histocompatibility gene complex exists in rat heterologous genes; C6 cells were inoculated in rats Triggering a strong immune rejection can make the tumor can not continue to grow or even self-healing, thus confusing the effect of treatment, especially when used in immunization and gene therapy research, there is a big flaw.