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目的探讨不同血液净化方式对残余肾功能的影响分析。方法我院进行血液透析治疗的尿毒症患者,随机分为高通量组(HFHD组)、低通量组(LFHD组)和透析联合灌流组(HD+HP组)各24例。比较三组患者的残余肾功能,β2微球蛋白和血磷水平。结果三组患者的残余肾功能均较治疗前有明显的下降(P<0.05),而HFHD组和HD+HP组患者的残余肾功能下降均明显低于LFHD组患者(P<0.05),而HFHD组和HD+HP组患者的残余肾功能下降比较,差异无统计学意义(P>0.05)。治疗后,HFHD组、HD+HP组患者的血脂、β2微球蛋白和血磷水平较治疗前明显降低(P<0.05),并且均明显低于LFHD组患者(P<0.05),而HFHD组与HD+HP组患者比较,差异无统计学意义(P>0.05)。结论高通量血液透析和血液透析联合血液灌注均可以有效的保护患者的残余肾功能,是肾功能衰竭患者的首先透析方法,值得临床推广。
Objective To investigate the effects of different methods of blood purification on residual renal function. Methods Patients with uremia treated by hemodialysis in our hospital were randomly divided into high-dose group (HFHD group), low-dose group (LFHD group) and dialysis combined with perfused group (HD + HP group). Residual renal function, β2 microglobulin, and serum phosphate levels were compared between the three groups. Results The remnant renal function in all three groups was significantly lower than that before treatment (P <0.05), while the residual renal function in HFHD group and HD + HP group was significantly lower than that in LFHD group (P <0.05) There was no significant difference in residual renal function between HFHD group and HD + HP group (P> 0.05). After treatment, the levels of serum lipids, β2 microglobulin and phosphorus in HFHD group and HD + HP group were significantly lower than those before treatment (P <0.05), and were significantly lower than those in LFHD group (P <0.05) Compared with HD + HP group, the difference was not statistically significant (P> 0.05). Conclusion High-throughput hemodialysis and hemodialysis combined with blood perfusion can effectively protect the residual renal function in patients with renal failure is the first dialysis method, worthy of clinical promotion.