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目的 :观察和分析血清β-人绒毛膜促性腺激素(β-HCG)及孕酮检测对于先兆流产的临床应用价值。方法 :选取行孕期检查的早期妊娠孕妇150例为研究对象,根据患者临床特点和妊娠结局不同将患者分为三组,其中A组患者50例为正常妊娠孕妇,B组患者42例为先兆流产孕妇,C组患者52例为难免流产孕妇,观察比较三组患者入选时孕酮和血清β-HCG水平差异,通过ROC曲线分析对数据进行灵敏度与特异度分析,确定单一检测和联合检测的临界值。结果 :与正常妊娠的A组比较,B组与C组孕酮及血清β-HCG水平均低于A组,差异有统计学意义。联合检测AUC值高于孕酮与β-HCG单项检测AUC值,联合检测孕酮取值孕酮取值20.34ng/m L,β-HCG取值12814.3m IU/m L时最大Youden指数为0.83,灵敏度为95.3%,特异度为87.6%。结论 :较低的血清孕酮和β-HCG水平可提示先兆流产孕妇不良妊娠结局发生风险的升高,联合检测此两项指标可提高预测不良妊娠结局的特异度,有助于提高预测的准确性。
Objective: To observe and analyze the clinical value of β-human chorionic gonadotropin (β-HCG) and progesterone detection in threatened abortion. Methods: One hundred and fifty cases of early pregnant women examined during pregnancy were selected as study subjects. Patients were divided into three groups according to their clinical features and pregnancy outcome. Among them, 50 cases in group A were normal pregnant women and 42 cases in group B were threatened abortion Pregnant women, group C 52 patients with unavoidable abortion pregnant women observed the comparison of three groups of patients on the selection of progesterone and serum levels of β-HCG differences, the data by ROC curve analysis of sensitivity and specificity to determine the single detection and joint detection of the critical value. Results: Compared with normal pregnancy group A, the levels of progesterone and serum β-HCG in group B and group C were lower than those in group A, the difference was statistically significant. The combined detection of AUC was higher than that of progesterone and β-HCG. The combined detection of progestin and progesterone was 20.34ng / m L and 12814.3m IU / m L, respectively. The maximum Youden index was 0.83 , The sensitivity was 95.3% and the specificity was 87.6%. CONCLUSIONS: Lower serum progesterone and β-HCG levels may indicate an increased risk of adverse pregnancy outcomes in threatened abortion. The combination of these two measures can improve the predictive accuracy of adverse pregnancy outcomes and improve the prediction accuracy Sex.