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目的 比较顿服米非司酮 10 mg和米非司酮 2 0 mg分次口服用于紧急避孕的有效性、副作用及对月经的影响。 方法 采用双盲随机比较试验方法 ,共接纳符合要求条件的育龄妇女 10 0例随机进入 组 ( n=5 0 )和 组 ( n=5 0 ) ,予以治疗。于预期下次月经日期的第 7d随访 ,了解避孕效果、副作用及月经的变化。 结果 按 Dixon法计算两组避孕有效率分别为 6 7.3%及 10 0 %,两组间比较有显著性差异 ( P<0 .0 5 )。各种副作用发生率较低 ,均在 10 %以内 ,两组相近 ;月经变化两组间无显著性差异 ( P>0 .0 5 )。 结论 米非司酮 10 mg口服 ,12 h加服 10 m g的用法与顿服米非司酮 10 m g相比 ,明显提高了紧急避孕有效率 ,而且副作用小 ,可以安全使用。
Objective To compare the efficacy, side effects and menstrual effects of oral administration of 10 mg of mifepristone and 20 mg of mifepristone orally once daily for emergency contraception. Methods A double-blind randomized controlled trial was conducted. A total of 100 women of childbearing age who met the requirements were randomly assigned to receive treatment (n = 50) and group (n = 50). Follow-up on Day 7 of the next menstrual period is expected to understand contraceptive effects, side effects and changes in menstruation. Results According to the Dixon method, the contraceptive effective rates of the two groups were respectively 6 7.3% and 100%, with significant differences between the two groups (P <0. 05). The incidence of various side effects was low, both within 10%, similar to the two groups; there was no significant difference in menstrual changes between the two groups (P> 0.05). Conclusion The use of 10 mg mifepristone orally for 12 h plus 10 m g at 12 h significantly improved the efficiency of emergency contraception compared with 10 m g mifepristone and showed fewer side effects and safe use.