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研究多药耐药相关蛋白基因（ＭＲＰｍＲＮＡ）的表达与喉癌患者临床病理特征之间的关系。方法：应用逆转录一多聚酶链式反应（ＲＴ－ＰＣＲ）技术，检测了３５例喉癌患者ＭＲＰｍＲＮＡ的表达。结果：喉癌组织中ＭＲＰｍＲＮＡ阳性表达率为４５．７％（１６／３５），其阳性表达强度在晚期肿瘤中明显增高（Ｐ＜０．０５），且与肿瘤颈淋巴结转移明显相关（Ｐ＜０．０１）。结论：ＭＲＰｍＲＮＡ在喉癌中的表达，不仅提示其在多药耐药中的重要作用，亦影响肿瘤播散、转移等生物学特性。
To study the relationship between the expression of multidrug resistance-related protein (MRP mRNA) and the clinicopathological characteristics of laryngeal cancer patients. Methods: The expression of MRP mRNA in 35 cases of laryngeal cancer patients was detected by reverse transcription-polymerase chain reaction (RT-PCR). Results: The positive expression rate of MRP mRNA in laryngeal carcinoma tissues was 45.7% (16/35). The positive expression of MRP mRNA in laryngeal carcinoma tissues was significantly higher in advanced stage tumors (P <0.05) and significantly correlated with cervical lymph node metastasis (P < 0.01). Conclusion: The expression of MRP mRNA in laryngeal carcinoma not only indicates its important role in MDR, but also affects the biological characteristics of tumor dissemination and metastasis.