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细胞介导免疫是一个复杂的系列反应过程,当抗原进入机体后,抗原呈递细胞呈递抗原信息给T细胞,使之被激活后变成辅助性T细胞(CD4+)。此时,CD4细胞又可分为分泌白细胞介素-2和干扰素-γ的辅助性T细胞(Th1)及分泌白细胞介素-10的辅助性T细胞(Th2)。在假丝酵母菌感染时,Th1反应激活中性粒细胞和巨噬细胞,促进宿主抗假丝酵母菌;Th2反应则抑制宿主的抗感染作用。细胞介导免疫在系统性假丝酵母菌感染中的作用一直存在争议,但在口腔黏膜抗假丝酵母菌感染中的作用是肯定的。
Cell-mediated immunity is a complex series of reaction processes. When the antigen enters the body, the antigen-presenting cells present antigen information to the T cells and become activated to become helper T cells (CD4 +). At this point, CD4 cells can be further divided into helper T cells (Th1) that secrete interleukin-2 and interferon-γ and helper T cells that secrete interleukin-10 (Th2). In Candida infection, Th1 response activates neutrophils and macrophages to promote host anti-Candida; Th2 response inhibits the host’s anti-infective effect. The role of cell-mediated immunity in systemic Candida infections has been controversial, but its role in oral mucosal anti-Candida infections is affirmative.