论文部分内容阅读
目的观察血管内自膨式支架成形术治疗颈动脉狭窄患者手术前后血清C反应蛋白(CRP)含量的变化,以及辛伐他汀对其的影响。方法颈动脉狭窄患者36例,随机分为治疗组(术后24h在常规治疗基础上加用辛伐他汀)19例和对照组(仅常规治疗)17例。采用免疫浊度法动态观察不同时间点血浆CRP含量。结果两组患者术后血清CRP含量显著升高(P<0.01);术后4周治疗组CRP显著降低(P<0.01),两组比较有显著性差异(P<0.01)。结论支架成形术可致血清CRP升高,辛伐他汀可降低CRP含量,具有抗炎、稳定斑块的作用,可应用于术后再狭窄的防治。
Objective To observe the changes of serum C-reactive protein (CRP) before and after operation in patients with carotid artery stenosis treated by endovascular stent implantation and the effect of simvastatin. Methods Thirty-six patients with carotid artery stenosis were randomly divided into treatment group (19 hours after conventional therapy plus simvastatin) and control group (routine treatment only), 17 cases. Immunoturbidimetry was used to observe the plasma CRP levels at different time points. Results The postoperative serum CRP levels were significantly increased in both groups (P <0.01). CRP was significantly lower in the four weeks after operation (P <0.01), with significant difference between the two groups (P <0.01). Conclusions Stent angioplasty can result in the increase of serum CRP. Simvastatin can reduce the content of CRP and has anti-inflammatory and stable plaque. It can be used in the prevention and treatment of postoperative restenosis.