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目前对幽门螺杆菌(Hp)感染性胃病通常给予二联或三联的抗生素治疗。抗生素治疗Hp感染虽具有积极的临床意义,但也存在很大不足,具体有:(1)不良反应;(2)耐药菌株产生;(3)费用高;(4)疗程长,患者依从性差;(5)疗效欠稳定等。其中耐药菌株的产生是目前抗生素应用中的突出问题,不但耐药菌比例逐年上升,而且出现了大量同时对3~4种抗生素耐药的菌株,采用多种抗生素联合治疗仍难以达到理想疗效。目前发现几种天然物质可以单独作用治疗Hp。现就这几种天然物质新的研究进展作一综述。
At present, Helicobacter pylori (Hp) infectious stomach diseases are usually treated with antibiotics in combination with two or three. Antibiotic treatment of Hp infection has a positive clinical significance, but there are also major deficiencies, in particular: (1) adverse reactions; (2) drug-resistant strains; (3) high cost; (4) long course of treatment, patients with poor compliance ; (5) efficacy is not stable and so on. Among them, the emergence of drug-resistant strains is a prominent problem in the application of antibiotics. Not only the proportion of drug-resistant bacteria increases year by year, but also a large number of strains resistant to 3 to 4 antibiotics at the same time. Combination therapy with multiple antibiotics is still difficult to achieve the desired effect . Several natural substances have been found to treat Hp alone. Now on these kinds of new research progress of natural substances are reviewed.