目的探讨围生期孕妇血清D-二聚体、血浆组织因子(TF)及组织因子抑制物(TFPI)检测的临床意义。方法随机选取围生期孕妇116例(其中82例为健康妊娠女性,34例为妊高征孕妇)及非妊娠健康女性47例,分别作为正常围生期组、围生期妊高征组及正常对照组。采用免疫比浊法测定各组血清D-二聚体浓度,酶联免疫吸附试验(ELISA)法测定血浆TF及TFPI浓度,分析其对围生期孕妇的临床意义。结果正常围生期组及围生期妊高征组血清D-二聚体、TF及TFPI的浓度要明显高于正常对照组,差异有统计学意义(P<0.05)。围生期妊高征组血清D-二聚体、TF及TFPI的浓度要明显高于正常围生期组,差异有统计学意义(P<0.05)。结论对围生期孕妇血清D-二聚体、血浆TF及TFPI进行监测,有利于及时发现妊高征等妊娠并发症,对于预防弥散性血管内凝血的发生及治疗也具有重要意义。 Objective To investigate the clinical significance of detection of serum D-dimer, tissue factor (TF) and tissue inhibitor of tissue factor (TFPI) in pregnant women during perinatal period. Methods One hundred and sixty-six pregnant women (82 healthy pregnant women, 34 pregnant women with PIH) and 47 healthy pregnant women were randomly selected as the normal perinatal period group, the perinatal PIH group Normal control group. The serum concentration of D-dimer was determined by immunoturbidimetry, and the plasma TF and TFPI concentrations were measured by enzyme-linked immunosorbent assay (ELISA). The clinical significance was analyzed. Results The concentrations of serum D-dimer, TF and TFPI in normal perinatal group and perinatal PIH group were significantly higher than those in normal control group (P <0.05). The levels of serum D-dimer, TF and TFPI in perinatal PIH group were significantly higher than those in normal perinatal group (P <0.05). Conclusion The monitoring of serum D-dimer, plasma TF and TFPI in pregnant women during perinatal period is conducive to timely detection of pregnancy complications such as PIH, which is also important for the prevention and treatment of disseminated intravascular coagulation.