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观察了贻贝多活素(MSM)对实验性血栓形成和血小板聚集的影响。大鼠经igMSM1.35、2.7和5.4g/(kg·d)连续28d后,对“旋转环法”所形成的大鼠实验性血栓有明显抑制作用,其血栓湿重分别为105.1、97.3和89.3mg,与生理盐水(NS)~-对照组的142.7mg相比较,差异非常显著(P<0.01);其血栓干重亦明显低于NS组(P<0.01)。同样的给药途径和剂量,MSM可抑制ADP诱导的大鼠血小板聚集,使其最大聚集率降低,聚集速度减慢,聚集抑制率分别为27％、33％和21％。MSM体外用药亦可降低胶原诱导的家兔血小板最大聚集率和聚集速度,抑制率分别为45％、58％和64％。结果表明,MSM可通过降低血小板的聚集功能从而抑制动脉血栓的形成。
The effect of mussel viability (MSM) on experimental thrombosis and platelet aggregation was observed. After rats were treated with igMSM1.35,2.7 and 5.4g/(kg·d) for consecutive 28 days, the experimental thrombus formed by the “spin ring method” was significantly inhibited, and the thrombus wet weight was 105.1, 97.3 and 89.3mg, compared with 142.7mg in saline (NS) ~-control group, the difference was very significant (P <0.01); the thrombus dry weight was also significantly lower than that in NS group (P <0.01). In the same route and dose, MSM inhibited ADP-induced platelet aggregation in rats, resulting in a decrease in the maximum aggregation rate, a slower aggregation rate, and an aggregation inhibition rate of 27%, 33%, and 21%, respectively. In vitro administration of MSM also reduced collagen-induced maximum platelet aggregation and aggregation rate in rabbits, with inhibition rates of 45%, 58%, and 64%, respectively. The results showed that MSM can inhibit the formation of arterial thrombus by reducing platelet aggregation.