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本研究从急性、亚慢性经皮实验二个方面观察了TGA对大鼠的肝脏损害作用。急性实验TGA剂量为30、100、300mg/kg,一次经皮染毒;亚慢性实验剂量为5、50、150ng/kg,1次/周涂皮,共10周,对照组均为蒸馏水。实验结果表明:TGA急性经皮染毒可致肝细胞坏死及胞浆疏松化、肝脏脏器系数增加。亚慢性实验上述改变较急性实验轻微。血糖浓度在急性、亚慢性实验中均明显下降,
This study from the acute and subchronic transdermal experiments in two aspects of TGA rat liver damage. Acute experimental TGA dose of 30,100,300 mg / kg, a transdermal drug exposure; subchronic experimental dose of 5,50,150 ng / kg, 1 / week Tupi, a total of 10 weeks, the control group were distilled water. The experimental results show that: TGA acute percutaneous toxicity can cause necrosis of liver cells and cytoplasm loose, liver organ coefficient increased. Subchronic experiments The above changes than the acute test slight. Blood glucose levels in acute and subchronic experiments were significantly decreased,