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目的:探讨小儿幽门螺杆菌(Hp)感染伴消化性溃疡的不同临床治疗方法的疗效。方法:将60例平均年龄(7±0.6)岁幽门螺杆菌感染伴消化性溃疡的患儿采用随机数字法平均分为3组,所有患者均阿莫西林和甲硝唑治疗,同时A组患者给予奥美拉唑2周治疗,B组患者给予雷尼替丁4周治疗,C组患者给予胶体枸椽酸铋4周治疗。治疗后再次应用快速尿素酶试验联合14C-尿素呼吸试验检查Hp感染,并通过胃镜检测患者溃疡愈合情况。结果:治疗后3组间疗效比较结果显示:3组患者治疗后差异比较有统计学意义(P<0.05);进一步行两两比较显示,A组(奥美拉唑组)患者及C组(胶体枸椽酸铋组)患者愈合人数、Hp根除人数均多于B组(雷尼替丁组)患者,愈合时间及Hp根除时间明显低于B组(雷尼替丁组)患者,差异比较有统计学意义(P<0.05);A组(奥美拉唑组)患者与C组(胶体枸椽酸铋组)患者比较差异无统计学意义(P>0.05)。结论:对幽门螺杆菌感染伴消化性溃疡的患儿行奥美拉唑或胶体枸椽酸铋联合甲硝唑及阿莫西林治疗可以显著缓解患者的症状,同时与雷尼替丁相比,其治愈时间比较短,值得临床推广应用。
Objective: To investigate the efficacy of different clinical treatment of Helicobacter pylori (Hp) infection in children with peptic ulcer. Methods: Sixty children with the average age of (7 ± 0.6) years with H. pylori infection and peptic ulcer were randomly divided into three groups with random number method. All patients were treated with amoxicillin and metronidazole. Patients in group A Given omeprazole for 2 weeks, ranitidine for 4 weeks in group B, and group C for 4 weeks for colloidal bismuth citrate. After treatment, rapid urease test combined with 14C-urea breath test to check the Hp infection, and by gastroscopy to detect ulcers in patients with healing. Results: The results of three groups after treatment showed that the difference between the three groups after treatment was statistically significant (P <0.05). Further comparisons showed that group A (omeprazole) and group C Colloidal bismuth citrate group), the number of patients with Hp eradication were more than those in group B (ranitidine), and the healing time and Hp eradication time were significantly lower than those in group B (ranitidine) (P <0.05). There was no significant difference between group A (omeprazole) and group C (colloidal bismuth citrate group) (P> 0.05). Conclusion: Omeprazole or colloidal bismuth citrate combined with metronidazole and amoxicillin in children with Helicobacter pylori infection and peptic ulcer can significantly relieve the symptoms of patients. Compared with ranitidine, The cure time is relatively short, it is worth clinical application.