目的:探讨前S1抗原(Pre S1Ag)与乙肝五项指标常见模式的相关性及在肝功能评价中的作用。方法:采用ELISA检测乙肝患者血清中乙肝五项指标和Pre S1Ag;酶速率法检测血清ALT和AST。结果:Pre S1Ag阳性组中,五项指标模式以“小三阳”所占比例最高,“大三阳”次之,2例为五项全阴性模式。HBs Ag(+)Pre S1Ag(+)组肝功能指标ALT、AST升高率显著高于HBs Ag(+)Pre S1Ag(-)组(P<0.05)。结论:Pre S1Ag与乙肝五项指标模式有一定相关性,可以作为HBV感染检测的重要补充及乙肝患者肝功能损害的辅助评价指标。 Objective: To investigate the correlation between Pre S1Ag and common patterns of five indicators of hepatitis B and its role in the evaluation of liver function. Methods: Five indexes of hepatitis B and Pre S1Ag in serum of patients with hepatitis B were detected by ELISA. Serum ALT and AST were detected by enzymatic rate method. Results: Pre S1Ag positive group, the five indicators model to “Sanyang ” the highest proportion of “Sansang Yang ” followed, two cases of five all-negative model. The increase rate of ALT and AST in HBs Ag (+) Pre S1Ag (+) group was significantly higher than that in HBsAg (+) Pre S1Ag (-) group (P <0.05). Conclusion: Pre S1Ag and hepatitis B five index patterns have a certain correlation, can be used as an important complement to detect HBV infection and hepatitis B patients with liver damage secondary evaluation index.