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目的 观察羟基喜树碱、5—氟脲嘧啶方案化疗对晚期消化系统恶性肿瘤的疗效。方法 35例病人均采用羟基喜树碱、5—氟脲嘧啶方案化疗2个周期以上,评定疗效、毒性。结果 35例病人总有效率(CR+PR)为31.4％,其中胃癌36.4％,大肠癌30.8％,胰腺癌28.6％,肝癌25％。结论 羟基喜树碱、5—氟脲嘧啶联合应用对晚期消化系统恶性肿瘤疗效较好,毒副作用较轻,值得临床进一步研究和推广。
Objective To observe the efficacy of hydroxycamptothecin and 5-fluorouracil regimen in the treatment of advanced digestive system malignancies. Methods 35 patients were treated with hydroxycamptothecin and 5 - fluorouracil chemotherapy for more than 2 cycles to evaluate the curative effect and toxicity. Results The total effective rate (CR + PR) of 35 patients was 31.4%, including 36.4% for gastric cancer, 30.8% for colorectal cancer, 28.6% for pancreatic cancer and 25% for liver cancer. Conclusions Combination of hydroxycamptothecin and 5-fluorouracil is effective in treating advanced digestive system malignant tumors with less toxic and side effects, which deserves further clinical research and promotion.