苯甲基异喹啉生物碱广泛分布于各科植物中，它还是许多自然界存在的生物碱的前体［１］。这类化合物的合成发展了取代异喹啉的合成化学，而且许多苯甲基异喹啉生物碱类化合物具有各种生理活性。例如：罂粟碱的盐酸盐具有舒张平滑肌和冠状血管的作用［２］，目前，临床用于... Benzyl isoquinoline alkaloids widely distributed in various plants, it is also the precursor of many alkaloids in nature [1]. The synthesis of these compounds has evolved to the synthetic chemistry of substituted isoquinolines, and many of the benzylisoquinoline alkaloids have a variety of physiological activities. For example: papaverine hydrochloride has the role of diastolic smooth muscle and coronary vessels [2], at present, the clinical ...