目的探讨经支气管镜冷冻联合局部化疗治疗晚期中心型肺癌的疗效与安全性。方法纳入2013年8月~2014年12月患者112例，男74例，女38例，年龄52~85岁，平均71岁。全部患者经支气管镜检查病理确诊，且均为晚期中心型肺癌，不能手术切除，体质相对较差，不能耐受全身化疗或不愿进行放化疗者。每周或每2w进行支气管镜下冷冻治疗，冷冻后给予顺铂20mg肿瘤组织中注射或喷洒。治疗1~5次不等，平均2.56次。对患者治疗前后的管腔再通状况、临床症状、胸部影像进行详细记录，并进行对比研究。结果治疗过程中除7例出血较多，3例无效外，无其他严重并发症，无手术死亡。主支气管及叶以上支气管管腔再通率达89/98(90.8%)。临床症状明显改善，改善率为咳嗽87/102(85.2%)、呼吸困难86/90(95.5%)、咯血35/41(85.3%)，临床总有效率97.32%；患者生活质量提高，随访2个月病情稳定。结论支气管镜下冷冻联合局部注射化疗药物，疗效确切，创伤小，可解除气道梗阻、快速缓解临床症状、改善生活质量。“,”Objective To evaluate the clinical ef ect and security of the cryotherapy combinedwith drug in late stage central lung cancer by fiberoptic bronchoscopy.Methods 112 patients were enrol ed in this study from 08.2013 to 12.2014,including 74male and 38 female.The average age was 71years ( ranged from 52 to 85years old) .Al 112 patients,received the cryotherapy combined with drug byfiberoptic bronchoscopy once 7~14 d.Cryotherapy was performed 287 times for al patients,2.56 times per patient on average.The trachea or bronchus station,symptom such as dyspnea, hemoptysis,cough were observed.Results The unblocked ratio of trachea and bronchea was 90.8%.Al patients got satisfiedimprovement ratio of symptoms,87/102 (85.2%) for cough ,86 /90( 95.5%) for dyspnea,35/41 ( 85.3%) for hemoptysis.The total ef ective rate was 97.32%.The Fol ow-up time was 2months.There was no severe perioperative complications and mortality except for 7 cases of oderate exeduation,3 cases of no ef ective .Conclusion The cryotherapy combined with drug for late stage central lung cancer by fiberoptic bronchoscopy was easy to perform with minimal wound.Not only could it providean ef ective and rapid control of symptoms caused by late stage central lung cancer it could also unobstructed bronchus promptly and improve patients quality of life.