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在三氟乙酸(TFA)作用下,烯胺酮(1)与烯胺酯(7或2)的[3C十3C]交叉缩合反应,主要形成2-胺基-4,6-二甲基苯甲酸甲酯(5)。讨论了三氟乙酸用最及不同的烯胺酮对[3C+3C]缩合反应中3的收率和产物分配的影响。烯胺酮在三氟乙酸作用下,可在温和的条件下自缩合,产物易于纯化。
Intercondensation of enaminone (1) with [3C10C] of the enamino ester (7 or 2) under the action of trifluoroacetic acid (TFA) leads to the formation of 2-amino-4,6-dimethylbenzene Methyl formate (5). The effect of trifluoroacetic acid on yield and product partitioning of [3 C + 3C] condensation reaction with the most different enaminones was discussed. Enaminone trifluoroacetic acid role in self-condensation under mild conditions, the product is easy to purify.