脂肪酸合成酶(fattyacid synthase,FAS)是脂肪酸合成过程中的关键酶。近年来发现,FAS与减肥、抗癌有着密切关系,因此开发FAS的抑制剂有望为相关疾病的治疗开拓新的途径。本文根据最近国内外研发动态,分别从该酶的减肥、抗癌机制、抑制剂开发等方面进行了综述,并对该酶及抑制剂的研究前景及发展趋势予以预估,以期为相关的研究提供有价值的参考。 Fatty acid synthase (FAS) is a key enzyme in fatty acid synthesis. In recent years, found that, FAS and weight loss, anti-cancer are closely related, so the development of inhibitors of FAS is expected to open up new avenues for the treatment of related diseases. Based on the recent developments both at home and abroad, this article summarized the research on weight loss, anti-cancer mechanism and the development of inhibitors, respectively, and forecasted the research prospects and development trend of the enzymes and inhibitors. Provide valuable reference.