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探讨血清非甲－戊急性肝炎的病因学。采用免疫组织化学技术对59例血清非甲－戊急性肝炎患者的肝组织，分别进行乙、丙和庚型肝炎病毒抗原检测，部分病例经原位杂交证实。结果59例血清非甲－戊急性肝炎患者，肝组织中乙、丙、庚型肝炎病毒抗原的检出例次分别为２９、１８、３５，其中乙、庚较丙型肝炎病毒抗原检出为高，差异显著（Ｐ＜０．０１）。单纯急性乙、庚及非甲－庚型肝炎部分肝功能比较差异无显著性（Ｐ＞０．０５）。经肝组织免疫组化进一步确定的急性非甲－戊型肝炎仅占４２．４％（２５／５９）。有１８．７％（１１／５９）仍为非甲－庚型肝炎。隐匿性的HBV、HGV感染是血清证实为急性非甲－戊型肝炎的主要病因。仍有部分病例为非甲－庚型肝炎，提示有另外的致病因子存在。
To explore the etiology of serum non-Acute hepatitis. Immunohistochemistry was used to detect the hepatitis B, C and C hepatitis in 59 patients with non-Acute hepatitis, and confirmed by in situ hybridization in some cases. Results Among the 59 cases of non-Acute hepatitis patients, the detection frequency of hepatitis B, C and G hepatitis viruses in the liver tissues were 29, 18 and 35, respectively. Among them, B and G were higher than those of hepatitis C virus antigen High, the difference was significant (P <0.01). There were no significant differences in the liver function between acute A, G and non-A-G hepatitis patients (P> 0.05). Only 42.4% (25/59) of acute non-A-hepatitis B were confirmed by immunohistochemistry of liver tissues. 18.7% (11/59) were still non-A-G hepatitis. Occult HBV, HGV infection is the main cause of acute non-A-Hepatitis confirmed by serum. There are still some cases of non-A - G hepatitis, suggesting that there are other virulence factors exist.