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目的:探讨小剂量HA配合GM-CSF治疗老年急性髓系白血病的近期疗效。方法:HHT 0.75 mg·m-2·d-1、Ara-C15 mg·m-2·d-1,静脉滴注,第1天~第10天,休息7 d ~ 10 d后重复,GM-CSF 100 mg·m-2·d-1,皮下注射,中性粒细胞>2×109/L即减量或停用观察。结果:13例患者经小剂量HA配合GM-CSF应用,获完全缓解(CR)4例,部分缓解(PR)6例,未缓解(NR)3例,CR率达30 %,有效率达76.9 %。结论:小剂量HA配合GM-CSF治疗老年急性髓系白血病近期疗效较好,毒副反应轻。
Objective: To investigate the short-term efficacy of low-dose HA combined with GM-CSF in the treatment of senile acute myeloid leukemia. METHODS: HHT 0.75 mg · m-2 · d-1 and Ara-C 15 mg · m-2 · d-1 were intravenously instilled on day 1 to day 10 and were resumed after 7 days to 10 days. GM- CSF 100 mg · m-2 · d-1, subcutaneous injection of neutrophils> 2 × 109 / L that is reduced or disable observation. Results: Thirteen patients with complete remission (CR), 6 with partial remission (PR) and 3 with no remission (NR) achieved a CR rate of 30% with an effective rate of 76.9 %. Conclusion: The low dose of HA combined with GM-CSF for the treatment of senile acute myeloid leukemia has better curative effect and less toxic side effects.