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上海巴斯德研究所肖晖教授和美国加利福利亚大学圣地亚哥医学院冯根生教授的合作研究,发现了酪氨酸磷酸酶SHP-2参与了C型凝集素受体介导的巨噬细胞和树突状细胞抗真菌免疫反应,该成果发表在2015年4月份的Nat Immunol杂志中。真菌,是一种广泛存在的病原微生物。相对于细菌和病毒而言,真菌不易引起全身性的感染。大多数由真菌感染引起的疾病,都只存在于皮肤和黏膜层。因此,真菌的感染机制和人体的抗真菌反应也一直没有得到很多的关注。但是,最近的10
Professor Xiao Hui from Pasteur Institute of Shanghai and Professor Feng Gensheng from San Diego Medical College of the University of California, San Diego, USA, found that tyrosine phosphatase SHP-2 is involved in C-type lectin receptor-mediated macrophage and Dendritic cell antifungal immune response, published in the April 2015 issue of Nat Immunol. Fungi, is a widespread pathogenic microorganism. Relative to bacteria and viruses, the fungus is not easy to cause systemic infection. Most diseases caused by fungal infections are found only on the skin and mucous membranes. Therefore, the fungal infection mechanism and the body’s antifungal response has not been a lot of attention. However, the most recent 10