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对癲痫患者的研究显示~(99)锝~m六甲基丙烯肟单光子发射型计算机断层显像(~(99)Tc~mHMPAO SPECT)和质子核磁光谱(′H MRS)检查有助于癲痫病灶的定位。在癫痫发作间期,使用SPECT检查,其敏感性儿童较成人高,但HMPAO的摄取受某些因素的影响,如神经细胞核的摄取比胶质细胞核要高;神经元减少时,摄入减少,胶质细胞增多时,摄入增加。~IH MRS则通过分析N—乙酰天门冬酸(NAA)。肌酸十磷酸肌酸(cr)和复合胆碱(cho)的信号标记来证实脑损害的存在。业已证明:NAA存在于脑内神经元,当神经元减少或受损时,NAA减少,癫痫患者的cr和cho增加。NAA/(cho+cr)比例的下降有助于确定癫痫病灶。
Studies on patients with epilepsy have shown that ~ (99) technetium ~ m hexamethonine oxime single photon emission computed tomography (~ 99 Tc ~ mHMPAO SPECT) and proton nuclear magnetic resonance spectroscopy (’H MRS) Location of epilepsy lesions. In the seizure interval, using SPECT examination, the sensitivity of children than adults, but the uptake of HMPAO by some factors, such as nerve cell nucleus uptake higher than the glial cell nucleus; decreased neurons decreased intake, Glial cells increased intake increased. ~ IH MRS was analyzed by N-acetyl aspartic acid (NAA). Creatine acid creatine phosphate (cr) and complex choline (cho) signal markers to confirm the existence of brain damage. It has been demonstrated that NAA is present in neurons in the brain and that NAA is reduced when neurons are reduced or impaired, and that cr and cho cholecysts are increased in epileptic patients. A decrease in the ratio of NAA / (cho + cr) can help identify epileptic lesions.