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通过糖类化合物３种常用基质ＭＡＬＤＩ－ＭＳ分析效果的比较以及寡糖和多糖正、负离子ＭＡＬＤＩ－ＭＳ谱的对比，找到了适合糖分析的基质２，５－ＤＨＢ，探讨了糖类化合物激光解吸／电离条件下形成离子的过程，指出了Ｎａ＋、Ｋ＋离子在寡糖分子量测定中的重要作用，借助柱层析分离手段，成功地测出了分子量大于１００００的葡聚糖的分子量．
Based on the comparison of MALDI-MS analysis results of three commonly used carbohydrates and comparison of positive and negative MALDI-MS spectra of oligosaccharides and polysaccharides, 2,5-DHB, a suitable substrate for sugar analysis, was found. The effects of laser desorption / Ionization conditions, and pointed out the important role of Na + and K + ions in the determination of molecular weight of oligosaccharides. By means of column chromatography, the molecular weight of dextran with molecular weight greater than 10,000 was successfully measured.