胰岛素样生长因子-I受体(IGF-IR)为酪氨酸激酶受体家族成员。IGF-IR与其相应的配体结合后,通过启动相关的信号传导通路可介导细胞的增殖、转化以及抑制细胞凋亡等生物学活性,与肿瘤的发生、发展、转移密切相关,因而成为肿瘤治疗的新靶点。本文集中介绍了IGF-IR的生物学特性、信号传导调控与肿瘤的关系以及针对IGF-IR的抗肿瘤治疗的新进展。 Insulin-like growth factor-I receptor (IGF-IR) is a member of the tyrosine kinase receptor family. IGF-IR binds with its corresponding ligand, and then activates relevant signal transduction pathways to mediate biological activities such as cell proliferation, transformation and apoptosis induction, and is closely related to tumorigenesis, development and metastasis, thus becoming a tumor New target for treatment. This article focuses on the biological characteristics of IGF-IR, the relationship between signal transduction regulation and tumor, as well as the new progress of antitumor therapy against IGF-IR.