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目的探讨氯沙坦联合复方肾炎片治疗慢性肾小球肾炎的临床疗效,为临床用药提供指导。方法将在我院接受治疗的64例慢性肾小球肾炎患者随机分为对照组和联合治疗组各32例。对照组采用氯沙坦治疗,联合治疗组在对照组的治疗基础上采用复方肾炎片进行联合治疗。结果联合治疗组24h尿蛋白、血清肌酐及尿素氮含量分别为0.8±0.2g、97.8±10.3μmol/L及5.8±0.4mmol/L,总有效率为89%,与对照组含量1.1±0.3g、118.4±15.7μmol/L及6.4±0.5mmol/L,总有效率78%相比较,具有显著性差异(P<0.05)。结论氯沙坦联合复方肾炎片对慢性肾小球肾炎具有显著的临床疗效,其效果优于单纯的氯沙坦用药,此法值得在临床进一步推广。
Objective To investigate the clinical efficacy of losartan combined with compound nephritis tablets in the treatment of chronic glomerulonephritis and provide guidance for clinical use. Methods 64 cases of chronic glomerulonephritis treated in our hospital were randomly divided into control group and combination therapy group, 32 cases each. The control group was treated with losartan. The combination therapy group was treated with compound nephritis tablets on the basis of the treatment of the control group. Results The 24 h urinary protein, serum creatinine and urea nitrogen of the combined treatment group were 0.8 ± 0.2g, 97.8 ± 10.3μmol / L and 5.8 ± 0.4mmol / L, respectively, with a total effective rate of 89% and the control group of 1.1 ± 0.3g , 118.4 ± 15.7μmol / L and 6.4 ± 0.5mmol / L, respectively. The total effective rate was 78%. There was a significant difference (P <0.05). Conclusion losartan combined with compound nephritis tablets in chronic glomerulonephritis has a significant clinical effect, its effect is better than simple losartan medication, this method deserves further promotion in the clinical.