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在一定的条件下,盐酸阿霉素(PMB)有电致化学发光现象,其发光强度受脉冲幅度、底液性质和金属离子的影响,并且在相同的脉冲幅度和一定的浓度范围内,PMB的发光强度与浓度在 1.36 × 10-7~ 8.8 × 10-6 mol/L范围内呈现良好的线性关系,可以用于测定药剂中PMB的含量。方法的检测限为3.0×10-8mol/L(S/N=3),RSD为3.6%(n=7)。
Under certain conditions, doxorubicin hydrochloride (PMB) has the phenomenon of electrochemiluminescence. Its luminescence intensity is affected by the pulse amplitude, the nature of the bottom liquid and metal ions, and in the same pulse amplitude and a certain concentration range, PMB The luminescence intensity and concentration ranged from 1.36 × 10-7 to 8.8 × 10-6 mol / L showed a good linear relationship, which can be used to determine the content of PMB in the drug. The detection limit of the method was 3.0 × 10 -8 mol / L (S / N = 3) and the RSD was 3.6% (n = 7).