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目的:观察以补肾疏肝为基方在提升体外受精-胚胎移植术(IEV-EF)成功率中的应用效果。方法:选取行IEV-EF治疗的不孕症患者60例作为研究对象,采用数字随机表将患者随机均分为观察组和对照组,对照组予以超促排卵治疗,观察组在对照组基础上予以补肾疏肝方加减治疗,行中医症状评分,观察两组促性先腺激素用量(Gn)、促卵泡生成素水平(FSH)、血清抑制素B水平(INH-B)、子宫内膜厚度等的变化情况,记录两组取卵数、受精率、优质胚胎率、妊娠率。结果:观察组Gn用量、FSH分别为(34.10±11.52)支、(7.46±1.68)m IU/ml,明显低于对照组;INH-B为(83.24±11.50)pg/ml,明显高于对照组,差异具有统计学意义(P<0.05)。观察组优质卵率和优质胚胎率分别为(0.84±0.21)%、(0.78±0.07)%,明显高优于对照组;临床妊娠率为66.66%,明显高于对照组的43.33%,差异具有统计学意义(P<0.05);观察组经色暗淡、经量不一、经前烦躁易怒、性欲减退评分分别为(4.85±0.71)分、(5.03±0.46)分、(5.12±0.46)分、(5.17±0.39)分,均显著高于对照组,差异具有统计学意义(P<0.05)。结论:以补肾疏肝为调养基方能够改善临床症状,减少Gn用量,降低促卵泡生成素水平,有利于提高优质胚胎率和临床妊娠率。
Objective: To observe the effect of kidney-tonifying and liver-diverting on the success rate of enhancing in vitro fertilization-embryo transfer (IEV-EF). Methods: Sixty infertility patients treated with IEV-EF were selected as the research object. The patients were randomly divided into observation group and control group using digital randomized table, and the control group was treated with hyperstimulation. On the basis of the control group The patients were treated with Bushen Shugan Decoction and TCM symptom score. The levels of Gn, FSH, INH-B, endometrium, Thickness and other changes recorded the number of oocytes retrieval, fertilization rate, high-quality embryo rate, pregnancy rate. Results: The amount of Gn in the observation group was (34.10 ± 11.52) and (7.46 ± 1.68) m IU / ml, respectively, which was significantly lower than that of the control group. The INH-B level was (83.24 ± 11.50) pg / Group, the difference was statistically significant (P <0.05). The rate of high-quality and high-quality embryos in the observation group was (0.84 ± 0.21)% and (0.78 ± 0.07)% respectively, which was significantly higher than that of the control group. The clinical pregnancy rate was 66.66%, significantly higher than that of the control group (43.33% (4.85 ± 0.71) points, (5.03 ± 0.46) points and (5.12 ± 0.46) points respectively in the observation group, the difference was statistically significant (P <0.05) (5.17 ± 0.39) points, which were significantly higher than those in the control group (P <0.05). Conclusion: Bushen Shugan as the basis for the maintenance of the radical can improve clinical symptoms, reduce the amount of Gn and reduce the level of follicle stimulating hormone, help to improve the quality of embryo and clinical pregnancy rate.