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早在六十年代即有用激素作为事后避孕药的报告,广泛使用大剂量雌激素口服5日法,其最大缺点为副作用发生率高。Yuzpe 改为雌孕激素合剂,共服两次,间隔12小时,由于所含雌激素总量较低,故副反应亦较小。丹那唑为从17-α-乙炔睾丸酮衍生而来的半合成甾体,长期应用特别是用于子宫内膜异位,恶心呕吐的副反应不明显。它具有明显的抗促性腺激素作用,亦能阻断卵巢滤泡、黄体及子宫内膜合成甾
As early as the sixties that useful hormones as a contraceptive report, the widespread use of large doses of estrogen orally 5 days, the biggest drawback is the high incidence of side effects. Yuzpe to estrogen and progesterone mixture, a total of two times, an interval of 12 hours, due to the lower total estrogen, so side effects are also smaller. Danazol is a semisynthetic steroid derived from 17-alpha-ethynyl testosterone. Long-term use of side-effects, especially for endometriosis, nausea and vomiting, is not obvious. It has obvious anti-gonadotropin effect, also can block ovarian follicular, corpus luteum and endometrial steroid