对１１４例不同类型和级别的结肠癌进行银染核仁形成区嗜银蛋白（Ａｇ－ＮＯＲｓ）形态定量研究．结果表明，Ａｇ－ＮＯＲｓ数量、大小和分布在结肠未分化癌和印戒细胞癌组与管状腺癌和粘液腺癌组比较，有明显差异．管状腺癌随分化程度的降低，Ａｇ－ＮＯＲｓ的数量、形态、大小和分布也发生等级性变化．结果提示，Ａｇ－ＮＯＲｓ形态定量的数量、形态、大小和分布４项指标对结肠癌分型有一定意义，对管状腺癌分级有较好的诊断价值。 A quantitative study of silver-stained nucleolar protein (Ag-NORs) morphology was performed in 114 different types and grades of colon cancer. The results showed that the number, size and distribution of Ag-NORs were significantly different between the undifferentiated colon cancer and signet ring cell carcinoma group and the tubular adenocarcinoma and mucinous adenocarcinoma group. With the decrease of the degree of differentiation of tubular adenocarcinoma, the quantity, morphology, size and distribution of Ag-NORs also changed hierarchically. The results suggest that the quantity, morphology, size and distribution of Ag-NORs quantification have a certain significance for the classification of colon cancer, and have a good diagnostic value for the classification of tubular adenocarcinoma.