胶质瘤是成人最常见的原发性脑肿瘤,抑癌基因p53突变在胶质瘤中十分常见,但其机制尚未明确。近期研究显示:P53蛋白能控制肿瘤干细胞的自我更新并抑制其多能性。与胶质瘤相关的p53调控因子Pict1、Nanog、Bcl2L12以及miRNA则可能为胶质瘤及其干细胞提供新的基因治疗靶点。活化脑肿瘤干细胞中的P53联合现行治疗方案可能成为胶质瘤有效的治疗方法。 Glioma is the most common primary brain tumor in adults. The mutation of tumor suppressor gene p53 is very common in glioma, but its mechanism is not yet clear. Recent studies have shown that P53 protein can control tumor stem cells self-renewal and inhibit their pluripotency. Pict1, Nanog, Bcl2L12 and miRNA, which are related to glioma, may provide new gene therapy targets for gliomas and their stem cells. The combination of P53 in activated brain tumor stem cells with current therapies may be an effective treatment for glioma.