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目的:探讨应用阿卡波糖治疗2型糖尿病餐后低血糖的疗效及阿卡波糖的应用价值。方法:选择我院收治的2型糖尿病患者进行回顾性分析,共72例,将72例患者随机分为2组,每组36例。治疗组均服用阿卡波糖,观察周期为4周。对照组36例均服用苯乙双胍,观察周期为4周。在此期间记录、分析和对比两组患者的餐后低血糖发生率、空腹血糖值和餐后血糖值。结果:对照组和治疗组均随着治疗时间的延长,低血糖的发生率逐渐下降。第四周后,治疗组的仅1例患者发生低血糖,而对照组有仍有5患者发生低血糖,两组的低血糖发生率无明显差异(P>0.05);对照组和治疗组的空腹血糖值(FPG)和餐后血糖值(2hPBG)在治疗前后有明显差异(P<0.05)。4周后,治疗组患者的平均空腹血糖值为5.63±0.02,平均餐后血糖值为7.32±0.15;对照组平均空腹血糖值为5.31±0.02,餐后血糖值为6.92±0.25。结论:阿卡波糖能有效治疗2型糖尿病,并降低餐后低血糖的发生率,有一定的临床价值。
Objective: To investigate the therapeutic effect of acarbose on postprandial hypoglycemia in type 2 diabetes mellitus and the application value of acarbose. Methods: A retrospective analysis was performed on type 2 diabetic patients admitted to our hospital. A total of 72 patients were randomly divided into two groups, 72 patients in each group, with 36 patients in each group. The treatment group were taking acarbose, observation period of 4 weeks. Control group, 36 cases were taking phenformin, the observation period of 4 weeks. During this period recorded, analyzed and compared the incidence of postprandial hypoglycemia, fasting blood glucose and postprandial blood glucose in both groups. Results: The control group and treatment group with the extension of treatment time, the incidence of hypoglycemia gradually decreased. After the fourth week, hypoglycemia occurred in only 1 patient in the treatment group, and hypoglycemia was still found in 5 patients in the control group. There was no significant difference in the incidence of hypoglycemia between the two groups (P> 0.05); in the control group and the treatment group Fasting blood glucose (FPG) and postprandial blood glucose (2hPBG) were significantly different before and after treatment (P <0.05). After 4 weeks, the average fasting blood glucose of the treatment group was 5.63 ± 0.02, the average postprandial blood glucose was 7.32 ± 0.15; the average fasting blood glucose of the control group was 5.31 ± 0.02, and the postprandial blood glucose was 6.92 ± 0.25. Conclusion: Acarbose can effectively treat type 2 diabetes and reduce the incidence of postprandial hypoglycemia, which has certain clinical value.