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本文报道了对围产期免疫接种无应答者再次免疫接种的结果。 作者按0、1和2月程序给1154名新生儿接种血源性乙型肝炎疫苗（437人接种5μg,717人接种10μg）,结果1093人（94.7％）产生良好的抗体应答,166人（15.2％）产生抗乙型肝炎核心抗原（HBcAg）抗体,45人无抗体应答。这45人到4岁时再以0、1和5月程序接种3针默克药厂的重组酵母乙型肝炎疫苗（33人接种10μg,12人接种5μg）,第3剂后1个月以及1、2和4年采集血样,用放射免疫法检测乙型肝炎表面抗原（HBsAg）和抗-HBs水平,酶免疫法检测抗-HBc,对结果进行统计分析。 结果表明,5μg组中HBsAg阳性和乙型肝炎e抗原（HBeAg）阴性母亲的婴儿无应答率明显高于10μg组,而HBsAg阳性和HBeAg阳性母亲的婴儿无应答率两组均最低。再用5μg和10μg重组酵母乙型肝炎疫苗给无应答者接种后,其抗-HBsAg滴度均高于10mIU/ml（包括1名仅接种1剂10μg重组疫苗的儿童,其滴度1年后仍高于100mIU/ml）;4年后,大约30％的儿童（10μg组为13/32、5μg组为1/12）抗体滴度仍高于100mIU/
This article reports the results of a second immunization of those who did not respond to perinatal immunization. The authors vaccinated 1154 newborns with a blood-borne hepatitis B vaccine in accordance with the 0, 1, and 2 month schedules (5 μg for 437 and 10 μg for 717). As a result, 1093 (94.7%) had good antibody responses and 166 15.2%) produced anti-hepatitis B core antigen (HBcAg) antibody, 45 no antibody response. The 45 men were vaccinated with 3-pin Merck’s recombinant yeast hepatitis B vaccine (10 μg in 33 and 5 μg in 12) by age of 4 years at 0, 1, and 5 months, one month after the third dose, and Blood samples were taken at 1, 2, and 4 years. The levels of HBsAg and anti-HBs were detected by radioimmunoassay and anti-HBc by enzyme immunoassay. The results were statistically analyzed. The results showed that the non-response rate of 5μg group HBsAg-positive and HBeAg-negative mothers was significantly higher than that of 10μg group, while HBsAg-positive and HBeAg-positive mothers had the lowest rate of infancy in both groups. Anti-HBsAg titers were all higher than 10 mIU / ml after inoculation of non-responders with 5 μg and 10 μg of recombinant yeast Hepatitis B vaccine (including 1 inoculated with 1 dose of 10 μg recombinant vaccine alone, with a titer of 1 year Still higher than 100 mIU / ml); after 4 years, antibody titers still remained above 100 mIU / ml in approximately 30% of children (1/13 in 10 μg and 1/12 in μg)