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目的:观察急性冠状动脉综合征(ACS)患者血清中生长分化因子-1(GDF-1)的水平及其变化的临床意义。方法:以2013年5月-2014年5月收治的ACS患者100例为研究对象,其中ST抬高型心肌梗死者(STEMI组)33例、非ST段抬高型心肌梗死者(NSTEMI组)32例、不稳定型心绞痛者(UA组)35例,以同期收治的30例非ACS成年人为对照组。比较四组患者血清中的GDF-1水平,探讨ACS与相关实验室指标的相关性。结果:四组组间的GDF-1水平差异均存在统计学意义,且正常组>UA组>NSTEMI组>STEMI组。肌钙蛋白I(CTnI)和CK-MB水平在四组间也存在显著差异,正常组上述指标水平低于ACS组;吸烟史、CTnI、CK-MB和GDF-1是ACS患者的危险因素;GDF-1水平与患者的年龄、吸烟史、是否合并高血压糖尿病、血脂指标中的TC和LDL以及CTnI、CK-MB显著负相关,与HDL显著正相关(P<0.05)。结论:血清GDF-1水平在正常对照组、UA组、NSTEMI组和STEMI组依次降低,且与患者的不良生活习惯、合并症、血脂指标及心肌坏死标志物相关,提示GDF-1是心肌的保护因子,建立良好的生活习惯,定时检测GDF-1水平,有利于及早发现先兆ACS。
Objective: To observe the clinical significance of the serum level of growth differentiation factor-1 (GDF-1) in patients with acute coronary syndrome (ACS). Methods: A total of 100 ACS patients admitted to our hospital from May 2013 to May 2014 were enrolled in this study. Among them, 33 were ST-elevation myocardial infarction (STEMI), NSTEMI (non-ST-segment elevation myocardial infarction) 32 cases, unstable angina pectoris (UA group) 35 cases, treated by the same period in 30 non-ACS adults as control group. The serum levels of GDF-1 in the four groups were compared to explore the association between ACS and related laboratory parameters. Results: The differences of GDF-1 levels between the four groups were statistically significant, and the normal group> UA group> NSTEMI group> STEMI group. The levels of CTnI and CK-MB were also significantly different among the four groups. The levels of CTnI, CK-MB and GDF-1 in ACS group were lower than those in ACS group. The smoking history, CTnI, CK- There was a significant negative correlation between GDF-1 level and patient’s age, smoking history, whether or not with hypertension, TC and LDL, CTnI, CK-MB in serum lipids, and HDL (P <0.05). Conclusions: The level of serum GDF-1 in the normal control group, UA group, NSTEMI group and STEMI group in turn decreased, and with the patient’s adverse habits, complications, blood lipid indicators and markers of myocardial necrosis, suggesting that GDF-1 is myocardial Protecting factors, establishing good habits, regular detection of GDF-1 levels, is conducive to early detection of threatened ACS.