近年来,随着抗生素治疗及临床监护水平的提高,败血症相关死亡率有所下降,但其并发症的发病率仍在上升,故其总死亡率仍高[1]。弥散性血管内凝血(disseminated intravascularcoagulation,DIC)作为其常见的并发症,虽其发病机制、病理过程复杂,但其中天然抗凝途径功能紊乱起着重要? In recent years, with the increase of antibiotic treatment and clinical monitoring, sepsis-related mortality has declined, but the incidence of complications is still rising, so the total mortality rate is still high [1]. As a common complication of disseminated intravascular coagulation (DIC), although its pathogenesis and pathological process are complex, the natural anticoagulation dysfunction plays an important role.