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目的 比较乙肝病毒携带 HBe Ag(+ )与 HBe Ag(- )产妇的乳汁、婴儿静脉血乙肝病毒血清标志物(HBVM)阳性率 ,了解其对垂直传播的影响 ,以采取相应的防治措施。方法 把乙肝病毒携带产妇按 HBe Ag(+ )与HBe Ag(- )分为两组各 35例 ,检测两组乳汁、婴儿静脉血及 1岁幼儿 HBVM,进行卡方检验。结果 母亲 HBe Ag(+ )组宫内感染率为 17.1% (6 / 35 ) ,乳汁 HBV- DNA阳性率为 40 % (14/ 35 ) ;而母亲 HBe Ag(- )组宫内感染率及乳汁 HBV-DNA阳性率仅为 2 .9% (1/ 35 )。结论 母亲 HBe Ag(+ )组的宫内感染率和乳汁 HBV- DNA阳性率明显高于 HBe Ag(- )组 ,(P<0 .0 1)。建议在围产期应重点监测 HBe Ag(+ )者 ,而 HBe Ag(- )者可与正常孕妇同样对待和处理。
OBJECTIVE: To compare the positive rates of serum and hepatitis B virus (HBVM) markers of milk and infant with HBeAg (+) and HBeAg (-) in hepatitis B virus (HBeAg) patients and to understand its effect on vertical transmission in order to take corresponding prevention and treatment measures. Methods HBsAg (+) and HBe Ag (-) were divided into two groups (n = 35) by HBeAg-carrying mothers. The two groups of breast milk, infant’s venous blood and 1 year old children’s HBVM were tested for chi-square test. Results The intrauterine infection rate was 17.1% (6/35) in HBe Ag (+) mothers and 40% (14/35) in HBV DNA in breast mothers. However, the intrauterine infection rate in the mother HBeAg (- The positive rate of HBV-DNA was only 2.9% (1/35). Conclusion The intrauterine infection rate and the positive rate of HBV DNA in the mother HBe Ag (+) group were significantly higher than those in the HBe Ag (-) group (P <0.01). It is recommended that HBeAg (+) be monitored during the perinatal period, while HBeAg (-) should be treated and treated as normal pregnant women.