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目的研究在维持性血液透析中动静脉内瘘与长期中心静脉导管两种不同通路对尿毒症患者血小板计数及其活化因子的影响。方法检测并比较两种通路初次透析患者透析开始时0个月、4个月和12个月时血小板计数(PLT)及β-血栓球蛋白(β-TG)、血小板第4因子(PF4)、血栓素B2(TXB2)的变化。结果透析4个月、12个月PLT、β-TG、PF4、TXB2较0月时有显著提高,但每次血液透析后较透析前血小板计数明显减少(P<0.05)。PLT、β-TG、PF4、TXB2在两种长期通路间无差异(P>0.05)。结论血液透析可使血小板计数,血小板活化因子β-TG、PF4、TXB2显著提高,而这两种长期通路之间无显著差异。
Objective To study the effects of two different pathways of arterio-venous fistula and long-term central venous catheter on the platelet count and activation factor of patients with uremia during maintenance hemodialysis. Methods The levels of platelet count (PLT), β-TG, platelet factor 4 (PF4), platelet factor 4 Thromboxane B2 (TXB2) changes. Results The levels of PLT, β-TG, PF4 and TXB2 were significantly increased at 4 months and 12 months after dialysis compared with those at 0 month. However, the platelet counts were significantly lower after hemodialysis than before dialysis (P <0.05). PLT, β-TG, PF4 and TXB2 had no difference between the two long-term pathways (P> 0.05). Conclusion Hemodialysis can significantly increase platelet count, platelet-activating factor β-TG, PF4 and TXB2, but there is no significant difference between these two long-term pathways.