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脑性瘫痪中,痉挛型所占比例最大,造成患儿肌肉痉挛、关节及骨骼畸形等,严重影响患儿的运动功能及社交能力。相对于其他类型,痉挛型脑性瘫痪是治疗效果相对较好的一型。在其治疗中曾探索应用了神经阻滞剂、脊神经后根切断术等治疗方法,疗效均不满意。近年来,A型肉毒毒素局部肌肉注射因为其具有可以选择性地使肌肉痉挛程度降低以及相对较小的毒副作用,引起了医疗界的广泛关注,开辟了脑性瘫痪治疗的新领域。现结合文献,就该型脑性瘫痪的A型肉毒毒素治疗作一综述。
Cerebral palsy, spasticity accounted for the largest proportion, resulting in children with muscle spasms, joint and skeletal deformities, etc., seriously affecting children’s motor function and social skills. Compared with other types, spastic cerebral palsy is a relatively good type of treatment. In its treatment has explored the application of nerve blockers, spinal dorsal rhizotomy and other treatment methods, the efficacy is not satisfied. In recent years, local intramuscular injection of botulinum toxin type A has attracted widespread attention in the medical community due to its ability to selectively reduce the degree of muscle spasms and its relatively small toxicity, opening up new areas for the treatment of cerebral palsy. Now combined with the literature on the type of cerebral palsy botulinum toxin A treatment is reviewed.