论文部分内容阅读
目的:为研究酒精性肝病(ALD)提供理想的动物模型。方法:模型组大鼠12只,采用50％酒精每日2次灌胃,同时给予酒精饮料饲养,连续14周,建立慢性酒精性肝损伤大鼠模型;应用光镜和电镜观察酒精对大鼠肝组织及超微结构的影响。结果:模型组所有大鼠均出现了脂肪肝;91.6％的动物发生了酒精性肝炎,部分大鼠(16.7％)可见肝脏间质反应性增生;对照组大鼠肝组织及超微结构均正常。结论:该方法可造成具有类似于人类ALD病理改变的大鼠模型。
Objective: To provide an ideal animal model for the study of alcoholic liver disease (ALD). Methods: Twelve rats in model group were fed with alcohol 50% twice daily and alcoholic beverages for 14 consecutive weeks to establish a rat model of chronic alcoholic liver injury. The effects of alcohol on rats Effects of liver tissue and ultrastructure. Results: Fatty liver appeared in all the rats in model group; alcoholic hepatitis occurred in 91.6% of the animals, and interstitial hyperplasia of liver was observed in some rats (16.7%). The liver tissue and ultrastructure of rats in control group were normal . Conclusion: This method can result in a rat model with pathological changes similar to human ALD.