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应用免疫组化方法对３６例各亚型软骨肉瘤、骨肉瘤以及骨Ｅｗｉｎｇ氏瘤、淋巴瘤各５例，进行了Ｓ－１００蛋白（Ｓ－１００）波形蛋白（ｖｉｒｎｅｎｔｉｎ，Ｖｉｍ）、α＿１－抗胰糜蛋白酶（ａｌｐｈａ１－ａｎｔｉｃｈｙｍｏｔｒｙｐｓｉｎ，ＡＡＣＴ）、溶菌酶（ｌｙｓｏｚｙｍｅ，Ｌｙｓｏ）、白细胞共同抗原（ｌｅｕｃｏｃｙｔｅｃｏｍｍｏｎａｎｔｉｇｅｎ，ＬＣＡ）、Ｌｅｕ７、ｏｓｔｅｏｎｅｃｔｉｎ（ＯＮ）、ＮＳＥ等八种免疫抗血清的检测，结果发现，Ｓ－１００、Ｌｙｓｏ可以作为成软骨性肿瘤瘤细胞的标记物，ＯＮ可以作为骨细胞骨母细胞样分化的标记物之一。作者讨论了各亚型软骨肉瘤、骨肉瘤的组织发生学，也探讨了间叶性软骨肉瘤与骨的Ｅｗｉｎｇ氏瘤、骨的淋巴瘤的鉴别诊断问题。
Immunohistochemistry was performed on S-100 protein (S-100) vimentin (Vim) and α_1-resistance in 36 cases of chondrosarcomas, osteosarcomas, and Ewing’s neoplasms and lymphomas. Eight antiserums, alpha1-antichymotrypsin (AACT), lysozyme (Lyso), leucocyte common antigen (LCA), Leu7, osteonectin (ON), and NSE, were detected. The results showed that S- 100, Lyso can be used as a marker for chondroblastoma cells, and ON can be used as one of the markers for osteoblast-like differentiation of bone cells. The authors discussed the histopathology of chondrosarcomas and osteosarcomas of various subtypes, and also explored the differential diagnosis of mesenchymal chondrosarcomas and bone Ewing’s neoplasms and bone lymphomas.