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目的:探讨Caveolin-1和nm23在乳腺癌组织中的表达及意义。方法:选取于我院就诊的172例乳腺癌患者的乳腺组织和40例乳腺增生患者的正常乳腺组织,采用免疫组化技术检测标本中Caveolin-1和nm23的表达,并分析其与患者的临床病理之间的关系。结果:免疫组化结果显示Caveolin-1和nm23在乳腺癌组织中的表达均低于正常乳腺组织(P<0.05),且两者的表达呈正相关(r=0.609,P<0.05);其中Caveolin-1的表达与乳腺癌的临床分期及淋巴结转移有关(P<0.05),nm23的表达与乳腺癌的临床分期、组织学类型及淋巴结转移有关(P<0.05)。结论:Caveolin-1和nm23的表达可能是乳腺癌发生发展的重要原因,可应用于临床诊治乳腺癌患者。
Objective: To investigate the expression and significance of Caveolin-1 and nm23 in breast cancer. Methods: The breast tissues from 172 breast cancer patients and 40 normal breast tissues from our hospital were selected for immunohistochemistry to detect the expression of Caveolin-1 and nm23, and to analyze their relationship with the clinical The relationship between pathology. Results: Immunohistochemistry showed that the expression of Caveolin-1 and nm23 in breast cancer tissues were lower than that in normal breast tissues (P <0.05), and the expression of Caveolin-1 and nm23 was positively correlated (r = 0.609, P <0.05) (P <0.05). The expression of nm23 was correlated with the clinical stage, histological type and lymph node metastasis (P <0.05) .Conclusion: The expression of nm23 in breast cancer is related to the clinical stage and lymph node metastasis of breast cancer. Conclusion: The expression of Caveolin-1 and nm23 may be the important reasons for the development of breast cancer, which may be used in the clinical diagnosis and treatment of breast cancer patients.