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目的:探讨健脾益智法治疗多发梗塞性痴呆(MID)的作用机制。方法:运用灌服小承气汤以及栓子注入的方法制作MID大鼠模型,光镜下对比观察各组大鼠脑组织形态结构的病理变化。结果:与其他3组比较,中药组大鼠脑组织损伤情况明显减轻。结论:健脾益智法可能是通过提高脑细胞对缺血缺氧的耐受力,减轻海马区细胞以及其他脑细胞的损伤,从而起到治疗MID的目的。
Objective: To investigate the mechanism of Jianpi Yizhi for the treatment of multi-infarct dementia (MID). Methods: MID model of rats was made by injecting Xiaochengqi Decoction and injection of emboli. The pathological changes of brain tissue morphology were observed under light microscope. Results: Compared with the other three groups, the damage of brain tissue in TCM group was significantly reduced. Conclusion: Spleen and Puzzle Method may play a role in the treatment of MID by increasing the tolerance of brain cells to hypoxia and hypoxia, reducing the damage of hippocampus cells and other brain cells.