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目的:探讨2型糖尿病患者糖尿病周围神经病变(DPN)的相关因素。方法:对401例行肌电图检查的2型糖尿病患者慢性并发症的资料进行回顾描述,采集患者的年龄、性别、文化水平、糖尿糖尿病病程、入院时收缩压、舒张压、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇、HDL-C)、甘油三酯(TG)、总胆固醇(TC)、纤维蛋白原(FIB)、糖化血红蛋白(HbA_1c)、入院时空腹血糖(FPG)、早餐后两小时后血糖(2hPG),对资料用Logistic回归进行分析,得出与DPN发生相关的因素。结果:多因素Logistic回归分析结果表明DPN独立的保护因素为文化水平;独立的危险因素为病程。结论:病程长的糖尿病患者发生DPN的危险增加;文化水平高的患者发生DPN的风险降低。
Objective: To investigate the related factors of diabetic peripheral neuropathy (DPN) in type 2 diabetic patients. Methods: The data of chronic complications of type 2 diabetic patients undergoing EMG were retrospectively described. The age, sex, educational level, duration of diabetes mellitus, systolic blood pressure, diastolic blood pressure, low density lipoprotein (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), total cholesterol (TC), fibrinogen (FIB), glycosylated hemoglobin (HbA 1c), fasting plasma glucose (FPG), two hours after breakfast blood glucose (2hPG), the data were analyzed by Logistic regression to find out the factors associated with the occurrence of DPN. Results: The multivariate Logistic regression analysis showed that the independent protective factors of DPN were cultural level; the independent risk factors were the course of disease. CONCLUSIONS: Diabetic patients with longer duration of diabetes have an increased risk of developing DPN; patients with high levels of education have a reduced risk of developing DPN.