【摘 要】
：
以铂类药物为基础的化疗成为晚期头颈部鳞癌(head and neck squamous cell carcinoma,HNSCC)综合治疗中不可缺少的部分.化疗可与放疗同步用于局部晚期HNSCC的根治性治疗,或用
【机 构】
：
安徽医科大学第一附属医院放疗科,安徽 合肥 230022复旦大学附属肿瘤医院放疗科,复旦大学上海医学院肿瘤学系,上海 200032;
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以铂类药物为基础的化疗成为晚期头颈部鳞癌(head and neck squamous cell carcinoma,HNSCC)综合治疗中不可缺少的部分.化疗可与放疗同步用于局部晚期HNSCC的根治性治疗,或用于具有高危因素的HNSCC术后辅助治疗,也可用于诱导化疗(新辅助化疗)或者放疗后的辅助化疗.同期放化疗在局部晚期HNSCC的治疗中尤其重要.几种常用的铂类药物在HNSCC的治疗中各有优势.本文简述铂类药物的药理作用及机制,比较铂类药物在HNSCC的疗效与毒性,并分析不同给药方式(单药或多药联合,每周或每3周)与给药剂量所带来的疗效与毒性差异,希望能对医师合理使用铂类药物治疗HNSCC有所裨益.
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